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can i drink alcohol with hydroxyzine

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MedlinePlus says alcohol can make the side effects of hydroxyzine worse, and that the medicine may make you drowsy. Ask your doctor or pharmacist about the safe use of alcohol with it. Do not drive until you know how it affects you.

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In this article
  1. What MedlinePlus says
  2. Drowsiness and driving
  3. What NIAAA adds
  4. What to do

What MedlinePlus says

MedlinePlus, from the National Library of Medicine, says hydroxyzine is used to relieve itching from allergic skin reactions, to relieve anxiety and tension, and as a calming agent before and after surgical anesthesia. It states that “Alcohol can make the side effects of hydroxyzine worse” and tells you to ask your doctor about the safe use of alcohol while taking it.

Drowsiness and driving

The page says the medicine may make you drowsy and advises: “Do not drive a car or operate machinery until you know how this medication affects you.” Alcohol also causes drowsiness, so the two together may add up. That is our reading of the two warnings.

What NIAAA adds

NIAAA lists antihistamines such as diphenhydramine and cetirizine as causing drowsiness and dizziness and a higher risk of overdose when mixed with alcohol. NIAAA’s list does not name hydroxyzine, so check your label.

What to do

  • Ask your pharmacist how long to wait between a dose and a drink.
  • Tell your doctor about all medicines and supplements you take.

This is general information, not medical advice.

People also ask

Does alcohol make hydroxyzine side effects worse?

MedlinePlus says yes: alcohol can make the side effects of hydroxyzine worse.

Can I drive after taking hydroxyzine?

MedlinePlus says not to drive until you know how the medicine affects you, because it may make you drowsy.

How long should I wait to drink after hydroxyzine?

We found no official page that gives a number of hours. Ask your pharmacist or doctor.

General information only, not medical or legal advice. If you have a health condition, take medicines or are pregnant, ask your doctor before drinking alcohol. Never drink and drive.

Sources

  1. MedlinePlus (NLM): Hydroxyzine, read 4 Nov 2026
  2. NIAAA (NIH): Harmful Interactions, Mixing Alcohol with Medicines, read 4 Nov 2026
Written by A to Z Alcohol Editorial Team · Published Jun 14, 2023 · Updated Nov 4, 2026
About · How we verify this · Editorial policy · Corrections

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